Inclusion Criteria:

          1. Age >18, with metastatic breast cancer, documented Her2+ by FISH/Dual-ISH, and/or IHC
             3+ staining, local determination of Her2+ allowed

          2. Progressive disease with history of prior treatment with trastuzumab and capecitabine
             for metastatic disease (unless deemed intolerable or ineligible for capecitabine by
             the investigator).

          3. Prior treatment with T-DM1 in any setting unless deemed intolerable or ineligible for
             T-DM1 by the investigator.

          4. Target or non-target lesions per RECIST 1.1.

          5. ECOG 0 or 1.

          6. In the opinion of the investigator, life expectancy >6 months.

          7. LVEF > 50% by ECHO or MUGA within 4 weeks prior to first study treatment.

          8. Cr Clearance > 50mL/min per institutional guidelines.

          9. Negative serum pregnancy test for women of child bearing potential within 14 days of
             first study treatment and must agree to use effective contraception through 30 days
             after last treatment.

             For subjects who can father children:

               -  Must agree not to donate sperm starting at time of informed consent and
                  continuing throughout the study period and for at least 30 days after the final
                  study drug administration.

               -  If sexually active with a person of childbearing potential in a way that could
                  lead to pregnancy, must consistently use a barrier method of birth control
                  starting at time of informed consent and continuing throughout the study and for
                  at least 30 days after the final dose of study drug administration.

               -  If sexually active with a person who is pregnant or breastfeeding, must
                  consistently use a barrier method of birth control starting at time of informed
                  consent and continuing throughout the study and for at least 30 days after the
                  final dose of study drug administration.

         10. Willing and able to provide written Informed consent.

         11. All toxicities related to prior cancer therapies must have resolved to < grade 1, with
             following exceptions: alopecia, neuropathy, which must have resolved to <Grade 2;
             congestive heart failure which must have been <grade 1 in severity at the time of
             occurrence and resolved completely.

         12. Adequate hematologic and hepatic function as defined by:

               -  Hemoglobin >9g/dL

               -  Absolute neutrophil count (ANC)>1000 cells/uL

               -  Platelets >100,000/uL

               -  Total bilirubin < 1.5 X upper limit of normal (ULN), except for subjects with
                  known Gilbert's disease, who may enroll if the conjugated bilirubin is < 1.5 X
                  ULN

               -  Transaminases (aspartate aminotransferase/serum glutamic oxaloacetic transaminase
                  [AST/SGOT] and alanine aminotransferase/serum glutamic pyruvic transaminase
                  [ALT/SGPT]) ≤ 2.5 X ULN (≤ 5 X ULN if liver metastases are present)

         13. CNS Inclusion - Based on screening contrast brain MRI, patients must have one of the
             following:

               -  No evidence of brain metastases

               -  Untreated brain metastases not needing immediate local therapy. For patients with
                  untreated CNS lesions > 2.0 cm on screening contrast brain MRI, discussion with
                  and approval from the medical monitor is required prior to enrollment

               -  Previously treated brain metastases

        A. Brain metastases previously treated with local therapy may either be stable since
        treatment or may have progressed since prior local CNS therapy, provided that there is no
        clinical indication for immediate re-treatment with local therapy in the opinion of the
        investigator.

        B. Patients treated with CNS local therapy for newly identified lesions found on contrast
        brain MRI performed during screening for this study may be eligible to enroll if all of the
        following criteria are met:

        i. Time since WBRT is ≥ 21 days prior to first dose of treatment, time since SRS is ≥ 7
        days prior to first dose of treatment, or time since surgical resection is ≥ 28 days ii.
        Other sites of disease assessable by RECIST 1.1 are present C. Relevant records of any CNS
        treatment must be available to allow for classification of target and non-target lesions

        Exclusion Criteria:

          1. Having previous treatment with vinorelbine and gemcitabine for metastatic disease.

          2. History of allergic reactions to trastuzumab except for grade 1/2 infusion reactions.

          3. History of allergic reactions to tucatinib.

          4. Any systemic anti-cancer therapy <14 days of first study treatment, including any
             experimental agents.

          5. Clinically significant cardiopulmonary disease including ventricular arrhythmia
             requiring therapy

               -  Uncontrolled hypertension (defined as persistent systolic blood pressure >
                  150mmHG and/or diastolic blood pressure >100mm Hg on antihypertensive medication)
                  or any history of symptomatic CHF

          6. Known history of HIV, Hep B/C or known chronic liver disease.

          7. Known MI or unstable angina in last 6 months prior to first study treatment

          8. Inability to swallow pills or significant GI disease, in the opinion of the
             Investigator that would preclude oral absorption of the medication.

          9. Are pregnant, breastfeeding, or planning pregnancy.

         10. CNS Exclusion - Based on screening brain MRI, patients must not have any of the
             following:

             A. Any untreated brain lesions > 2.0 cm in size, unless discussed with medical monitor
             and approval for enrollment is given.

             B. Ongoing use of systemic corticosteroids for control of symptoms of brain metastases
             at a total daily dose of > 2 mg of dexamethasone (or equivalent). However, patients on
             a chronic stable dose of ≤ 2 mg total daily of dexamethasone (or equivalent) may be
             eligible with discussion and approval by the medical monitor.

             C. Any brain lesion thought to require immediate local therapy, including (but not
             limited to) a lesion in an anatomic site where increase in size or possible
             treatment-related edema may pose risk to patient (e.g. brain stem lesions). Patients
             who undergo local treatment for such lesions identified by screening contrast brain
             MRI may still be eligible for the study based on criteria described under CNS
             inclusion criteria.

             D. Known or suspected LMD as documented by the investigator. E. Have poorly controlled
             (> 7days) generalized or complex partial seizures, or manifest neurologic progression
             due to brain metastases notwithstanding CNS-directed therapy

         11. Use of a strong CYP3A4 or CYP2C8 inhibitor within ≤14days, or use of a strong CYP3A4
             or CYP2C8 inducer within ≤5 days prior to the first study treatment. CYP3A4 or CYP2C8
             inducers and inhibitors are also prohibited as concomitant medications within ≤14 days
             of initiating Tucatinib treatment. . Use of sensitive CYP3A substrates should be
             avoided two weeks before enrollment and during study treatment. See Appendices C, D, E
             for references. (See Section 7.6 for additional prohibited concomitant medications)

         12. Prior radiation therapy less than 7 days from start of treatment.

         13. Other medical, social, or psychosocial factors that, in the opinion of the
             investigator, could impact safety or compliance with study procedures.