Inclusion Criteria:

          -  Diagnosis of NB as defined by histopathology (confirmed by the MSK Department of
             Pathology), BM metastases plus high urine catecholamine levels, or positivity in MIBG
             scan.

          -  HR-NB, defined as MYCN-amplified stage 2/3/4/4S at any age and MYCN-nonamplified stage
             4 in patients >18 months old.

          -  No more than one prior cycle of chemotherapy.

          -  Age >1 year to <13 years old.

          -  Organ function requirements:

        Adequate renal function defined as:

        Creatinine clearance or radioisotope GFR ≥ 70 mL/min/1.73 m^2 or A serum creatinine based
        on age/sex as follows:

        Age: 1 to < 2 years Maximum Serum Creatinine (mg/dL): Male, 0.6; Female, 0.6 Age: 2 to < 6
        years Maximum Serum Creatinine (mg/dL): Male, 0.8; Female, 0.8 Age: 6 to ≤ 10 years Maximum
        Serum Creatinine (mg/dL): Male, 1; Female, 1

        The threshold creatinine values in this Table were derived from the Schwartz formula for
        estimating GFR utilizing child length and stature data published by the Centers for Disease
        Control.

        Adequate liver function defined as:

        Total bilirubin ≤ 1.5 x upper limit of normal (ULN) for age, and serum alanine
        aminotransferase (ALT) < 10 x ULN.

        Adequate cardiac function defined as:

        Shortening fraction of ≥ 27% by echocardiogram, or Ejection fraction of > 50% by
        echocardiogram or radionuclide angiogram.

          -  Signed informed consent indicating awareness of the investigational nature of this
             treatment.

        Exclusion Criteria:

          -  Severe dysfunction of major organs, i.e., renal, cardiac, hepatic, neurologic,
             pulmonary, hematologic, or gastrointestinal toxicity ≥ grade 3.

          -  Inability to comply with protocol requirements.

          -  Pregnancy is not an issue because all patients will be pre-adolescents.