Inclusion Criteria:

          -  Has pathologically (histologically or cytologically) confirmed diagnosis of squamous
             or nonsquamous non-small cell lung cancer (NSCLC)

          -  Has Stage IV (T any, N any, M1a, M1b, or M1c - American Joint Committee on Cancer 8th
             Edition) squamous or nonsquamous NSCLC

          -  Has confirmation that epidermal growth factor receptor (EGFR), Anaplastic lymphoma
             kinase (ALK), or ROS Proto-Oncogene 1, Receptor Tyrosine Kinase (ROS1)-directed
             therapy is not indicated in nonsquamous NSCLC as well as mixed nonsquamous/squamous
             NSCLC. Participants with purely squamous NSCLC do not require testing

          -  Has not received prior systemic treatment for their metastatic NSCLC. Participants who
             received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant
             therapy was completed at least 12 months prior to the development of metastatic
             disease

          -  Has an Eastern Cooperative Oncology Group (ECOG) performance score (PS) of 0 or 1

          -  Male participants are eligible to participate if they agree to use contraception as
             per protocol unless confirmed to be azoospermic

          -  A female participant is eligible to participate if she is not pregnant or
             breastfeeding, and at least one of the following conditions applies: is not a woman of
             childbearing potential (WOCBP) or is a WOCBP who agrees of using a contraceptive
             method per protocol

          -  Has measurable disease per Response Evaluation Criteria in Solid Tumors Version 1.1
             (RECIST 1.1) as assessed by the local site investigator/radiology

          -  Submit an archival tumor tissue sample or newly obtained core or incisional biopsy of
             a tumor lesion not previously irradiated for PD-L1 status determination prior to
             randomization

          -  Has adequate organ function

        Exclusion Criteria:

          -  Has a known additional malignancy that is progressing or has required active treatment
             within the past 3 years

          -  Has known central nervous system (ie, brain and/or spinal cord) metastases and/or
             carcinomatous meningitis. Participants with treated brain metastases may participate
             only if they satisfy all of the following: a) Have no evidence of new or enlarging
             brain metastases confirmed by post-treatment repeat brain imaging performed at least 4
             weeks after pretreatment brain imaging, and b) Are neurologically stable without the
             need for steroids for at least 14 days before first dose of trial treatment as per
             local site assessment

          -  Has severe hypersensitivity to study intervention and/or any of its excipients

          -  Has an active autoimmune disease that has required systemic treatment in past 2 years

          -  Has a history of (noninfectious) pneumonitis/interstitial lung disease that required
             steroids or has current pneumonitis/interstitial lung disease

          -  Has an active infection requiring systemic therapy

          -  Has a known history of human immunodeficiency virus (HIV) infection and/or Hepatitis B
             infection or known active Hepatitis C infection

          -  Has a known psychiatric or substance abuse disorder that would interfere with the
             participant's ability to cooperate with the requirements of the study

          -  Has symptomatic ascites or pleural effusion. A participant who is clinically stable
             after treatment for these conditions is eligible

          -  Before the first dose of study intervention: a) Has received prior systemic cytotoxic
             chemotherapy for metastatic NSCLC b) Has received antineoplastic biological therapy
             for metastatic NSCLC c) Has had major surgery (<3 weeks prior to first dose) d) Has
             received prior therapy with an anti-programmed cell death 1 (anti-PD-1),
             anti-programmed cell death ligand 1 (anti-PD-L1), or anti-programmed cell death ligand
             2 (anti-PD-L2) agent or with an agent directed to another stimulatory or coinhibitory
             T-cell receptor

          -  Received radiation therapy to the lung that is >30 Gray within 6 months of the first
             dose of study intervention

          -  Is expected to require any other form of antineoplastic therapy while on study

          -  For participants with nonsquamous histology: Is unable to interrupt aspirin or other
             Non-steroidal anti-inflammatory drugs (NSAIDs), other than an aspirin dose ≤1.3 g/day,
             for a 5-day period

          -  For participants with nonsquamous histology: Is unable or unwilling to take folic acid
             or vitamin B12 supplementation

          -  Has received prior radiotherapy within 2 weeks of start of study intervention.
             Participants must have recovered from all radiation-related toxicities, not require
             corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted
             for palliative radiation (≤2 weeks of radiotherapy) to non-CNS disease

          -  Has received a live or live attenuated vaccine within 30 days prior to the first dose
             of study intervention

          -  Is currently participating in or has participated in a study of an investigational
             agent or has used an investigational device within 4 weeks prior to the first dose of
             study intervention

          -  Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
             or any other form of immunosuppressive therapy within 7 days prior the first dose of
             study intervention

          -  Has had an allogenic tissue/solid organ transplant