Inclusion Criteria:

          -  Patient has a minimum life expectancy of 6 months

          -  Histological or cytological confirmation of prostate cancer, BC, NSCLC and any other
             solid tumors

          -  Confirmed metastatic disease by imaging

          -  Documented disease progression following first or later lines of anticancer systemic
             treatment

          -  Patient is eligible for low-dose EBRT for at least one lesion

          -  Patients with prior RT are eligible, only if there is no potential for field overlap
             between the prior RT and the planned RT

          -  For patients with BC or NSCLC: Patient must have at least one measurable lesion as per
             RECIST v1.1 (in Part 2 only)

          -  Patient has ECOG performance status of 0 to 2

          -  Adequate bone marrow, renal, and liver function

          -  Metastatic Castration-resistant Prostate Cancer: Baseline testosterone levels ≤ 14.4
             ng/dL and ongoing medical castration must be maintained throughout the duration of the
             study; patient has evidence of symptomatic and/or progressive disease

          -  Breast Cancer Patients: Known hormone receptor status (estrogen receptors/progesterone
             receptors or estrogen receptors alone). Breast cancer patients are allowed to be on
             background hormonal treatment.

        Exclusion Criteria:

          -  Patient has tumor involvement of the central nervous system

          -  Impaired cardiac functioning or clinically significant cardiac disease

          -  Uncontrolled hypertension despite two concomitant antihypertensive therapies

          -  Patients who have had a colectomy (total or left hemicolectomy) with re-anastomosis

          -  Patients for whom administration of the suppositories are likely to cause pain or
             difficulties in absorption

          -  Patients with fecal impaction or uncontrolled irritable bowel disease

          -  Patients with inflammatory bowel disease

          -  Any other disease, metabolic dysfunction, physical examination finding or clinical
             laboratory finding that, in the Investigator's opinion, gives reasonable suspicion of
             a disease or condition that contraindicates the use of an investigational drug, may
             affect the interpretation of the results, render the patient at high risk from
             treatment complications or interferes with obtaining informed consent

          -  Patients with oligometastatic disease (fewer than 5 metastatic lesions) amenable to
             standard therapy will be excluded

          -  Patients who have had RT to the region of the rectum or will require RT to the region
             of the rectum during the trial

          -  Uncontrolled active infection requiring intravenous antibiotic, antiviral or
             anti-fungal medications within 14 days before the first dose administration

          -  Receiving or having received anticancer treatment

          -  Patient has received corticosteroids at a dose of > 10 mg prednisone/day or equivalent
             for any reason within 4 weeks prior to receiving the first dose administration

          -  Patient is not willing to use suppositories

          -  Patient has a positive reverse transcription polymerase chain reaction (RT-PCR) test
             for severe acute respiratory coronavirus 2 (SARS-CoV-2) prior to Screening or
             enrollment, or has clinical signs and symptoms consistent with SARS-CoV-2 infection;
             e.g., fever, dry cough, dyspnea, sore throat, fatigue or positive SARS-CoV-2 test
             result within 2 weeks prior to Screening.