MetaboMed is developing MTB-9655, an orally bioavailable, first-in-class small molecule
inhibitor of the human Acetyl coenzyme A (Acyl-CoA) synthetase short chain family member 2
(ACSS2) enzyme, as a potential treatment for patients with cancer.
This study is a Phase 1,First-in-Human (FIH), open-label dose-escalation study of MTB-9655
given daily as a single oral (PO) agent. Up to 30 patients with locally advanced,
unresectable and/or metastatic solid tumor(s) are expected to be enrolled in the
dose-escalation portion (Part A). The study will be conducted at 1 to 2 sites in the United
States and Israel.
This Phase 1 First-in-Human (FIH) study is to initiate clinical development of MTB-9655 in
patients with advanced solid tumors who have failed or refused standard treatment, or who
have a tumor for which no therapy of proven efficacy exists. This study of MTB-9655 may
consist of 2 parts: a dose-escalation part to establish a safe and tolerable dose of MTB-9655
in patients with advanced or metastatic solid tumors for which no standard therapy is
available or standard therapy has failed (Part A), and a dose expansion phase (Part B) which
may be initiated at the Sponsor's discretion after the maximum tolerated dose (MTD) (or
recommended Phase 2 dose [RP2D]) has been determined in the dose-escalation (Part A), and
with approval of an amendment to the protocol. This study will be the basis for future
studies. The study will identify the safety and tolerability of MTB-9655 when administered on
a continuous dosing schedule (given by mouth on a 21-day schedule).
1. Signed written informed consent.
2. Patient is at least 18 years-of-age at the time of signature of the informed consent
3. Patient has an Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0
4. Patient must have a confirmed diagnosis of locally advanced, unresectable and/or
metastatic solid tumor(s), have failed standard treatment, or refuse standard
treatment, or have a tumor for which no therapy of proven efficacy exists, or a tumor
that is not amenable to standard therapies.
5. Patient has measurable disease on imaging based or non-measurable disease.
6. Patient will be requested to provide a fresh pre-treatment biopsy specimen, otherwise
they are required to provide an archival diagnostic tumor sample that is <1 year old.
7. Patient has a life expectancy ≥3 months according to the Investigator's judgment.
8. Women of child-bearing potential (WOCBP) must have a negative serum pregnancy test at
screening within 72 hours of first dose of MTB-9655. In addition, WOCBP are required
to use two forms of acceptable contraception.
9. Male patients with WOCBP partners must agree to use highly effective contraceptive
measures throughout the study starting with screening visit through 120 days after the
Patients who meet any of the following criteria will be excluded from study entry:
1. Treatment with any of the following:
- Any systemic anti-cancer chemotherapy, small molecule, biologic, or hormonal
agent from a previous treatment regimen or clinical study within 28 days or 5
half-lives (whichever is shorter) prior to the first dose of study drug. At least
10 days must have elapsed between the last dose of such agent and the first dose
of study drug.
- Wide-field radiotherapy administered ≤28 days or limited field radiation for
palliation ≤7 days prior to starting study drug.
- Major surgery(excluding placement of vascular access) within 3 weeks of first
dose of study drug.
- Prior treatment with other drug with the same mechanism of action (directed to
- Receiving systemic corticosteroid therapy 1 week prior to the first dose of study
drug or receiving any other form of systemic immunosuppressive medication for
medically significant acute or chronic conditions.
2. Persistent toxicity of National Cancer Institute Common Terminology Criteria for
Adverse Events (NCI CTCAE) Grade >1 severity that is related to prior therapy.
3. Central nervous system tumor, metastasis(es), and/or carcinomatous meningitis
identified either on the baseline brain imaging obtained during the screening period
or identified prior to consent.
4. Active infection requiring treatment.
5. Out-of-range laboratory values defined as:
- Absolute neutrophil count (ANC) <1.5 × 10^9/L
- Hemoglobin <9 g/dL
- Platelets <100 × 10^9/L)
- Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) >2.5 × the
upper limit of normal (ULN) or ≥5 × ULN with liver involvement
- Total bilirubin >1.5 × ULN
- Serum creatinine >1.5 × ULN or creatinine clearance (CrCl≤60mL/min, measured or
calculated using the Cockcroft-Gault Method
- International Normalized Ratio (INR) or prothrombin time (PT) >1.5 × ULN and
activated partial thromboplastin time (aPTT) >1.5 × ULN (unless patient is
receiving anticoagulant therapy)
6. Inability to swallow oral medications or presence of active gastrointestinal disease
or other condition that will interfere significantly with the absorption,
distribution, metabolism, or excretion of MTB-9655 (e.g., ulcerative disease,
uncontrolled nausea, vomiting, diarrhea Grade ≥2, malabsorption syndrome).
7. Any of the following cardiac criteria:
- Known history of marked prolongation of QT/corrected QT(QT/QTc) interval.
- Clinically significant cardiovascular disease, including cerebral vascular
accident/stroke or myocardial infarction within 6 months of enrollment, unstable
angina, congestive heart failure,or serious uncontrolled cardiac arrhythmia
- History of additional risk factors for Torsade de Pointes (including heart
failure, hypokalemia, family history of long QT syndrome, and use of concomitant
medications that prolong the QT/QTc interval.
- Patients with a left ventricular ejection fraction (LVEF) <50%.
8. History of concomitant malignancy with recurrence <3 year from enrolment.
9. Expected to require any other form of systemic or localized antineoplastic therapy
while on trial.
10. Significant liver cirrhosis defined as Child-Pugh Class B or C.
11. History of hemolytic disorders.
12. Active infection with human immunodeficiency virus (HIV).
13. History or current evidence of any condition, therapy, or laboratory abnormality that
might confound the results of the study, interfere with the patient's participation
for the full duration of the study, or is not in the best interest of the patient to
participate, in the opinion of the treating Investigator.
14. Pregnant or breastfeeding.