NCI Definition: A form of melanoma occurring most often on the plantar, palmar, subungual, and periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, it consists of atypical spindled and dendritic melanocytes. The epidermis is often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic cells. [1]

Acral lentiginous melanomas most frequently harbor alterations in CDKN2A, NRAS, BRAF, CDKN2B, and CCND1 [2].

Most Commonly Altered Genes in Acral Lentiginous Melanoma

NRAS Mutation, CDKN2A Loss, CDKN2B Loss, CCND1 Amplification, and FGF19 Amplification are the most common alterations in acral lentiginous melanoma [2].

Top Alterations in Acral Lentiginous Melanoma

Significant Genes in Acral Lentiginous Melanoma


CDK4 +



Disease Details

Acral Lentiginous Malignant Melanoma
Cutaneous Melanoma
OncoTree Name
Acral Melanoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.