Overview

NCI Definition: An adenoma of the pituitary gland that produces corticotropin. The vast majority of cases are associated with Cushing disease. Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily. Silent or hormonally non-functioning ACTH producing adenomas have also been described. They produce symptoms of a mass-related lesion. [1]

Disease Details

Synonyms
Adrenocorticotropin Producing Adenoma of Pituitary Gland, Corticotropin Secreting Adenoma of the Pituitary, ACTH Secreting Adenoma of Pituitary, Adrenocorticotropin Secreting Adenoma of the Pituitary Gland, Pituitary ACTH Secreting Adenoma, ACTH-Secreting Adenoma of Pituitary, Pituitary Gland ACTH-Secreting Adenoma, Adrenocorticotropin Secreting Adenoma of Pituitary, Corticotropin Secreting Pituitary Gland Adenoma, Adrenocorticotropin Producing Adenoma of the Pituitary, Adrenocorticotropin Producing Pituitary Adenoma, Corticotroph Adenoma, Pituitary Corticotropin Secreting Adenoma, ACTH-Secreting Adenoma of Pituitary Gland, Adrenocorticotropin Producing Pituitary Gland Adenoma, Adrenocorticotropin Secreting Pituitary Adenoma, Adrenocorticotropin Secreting Adenoma of the Pituitary, ACTH-Secreting Adenoma of the Pituitary Gland, Adrenocorticotropin Producing Adenoma of Pituitary, Corticotropinoma, Adrenocorticotropin Secreting Adenoma of Pituitary Gland, Adrenocorticotropin Producing Adenoma of the Pituitary Gland, Pituitary ACTH-Secreting Adenoma, ACTHoma, ACTH-Secreting Adenoma of the Pituitary, Adrenocorticotropin Secreting Pituitary Gland Adenoma, ACTH Secreting Adenoma of the Pituitary, ACTH Producing Pituitary Gland Adenoma
Parent(s)
Pituitary Gland Adenoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.