ACTH-Producing Pituitary Gland Adenoma
NCI Definition: An adenoma of the pituitary gland that produces corticotropin. The vast majority of cases are associated with Cushing disease. Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily. Silent or hormonally non-functioning ACTH producing adenomas have also been described. They produce symptoms of a mass-related lesion. 
There is 1 clinical trial for ACTH-producing pituitary gland adenoma, of which 1 is open and 0 are completed or closed. Of the trial that contains ACTH-producing pituitary gland adenoma as an inclusion criterion, 1 is phase 2 (1 open).
Vorinostat is the most common intervention in ACTH-producing pituitary gland adenoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.