Overview

NCI Definition: An adenoma of the pituitary gland that produces corticotropin. The vast majority of cases are associated with Cushing disease. Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily. Silent or hormonally non-functioning ACTH producing adenomas have also been described. They produce symptoms of a mass-related lesion. [1]

Disease Details

Synonyms
Corticotropin Secreting Pituitary Gland Adenoma, Adrenocorticotropin Producing Adenoma of Pituitary, ACTH-Secreting Adenoma of the Pituitary, ACTH Producing Pituitary Gland Adenoma, ACTH Secreting Adenoma of the Pituitary, ACTH-Secreting Adenoma of Pituitary Gland, Adrenocorticotropin Producing Pituitary Gland Adenoma, ACTH Secreting Adenoma of Pituitary, ACTH-Secreting Adenoma of the Pituitary Gland, ACTHoma, Pituitary ACTH-Secreting Adenoma, Adrenocorticotropin Producing Adenoma of Pituitary Gland, Adrenocorticotropin Secreting Pituitary Gland Adenoma, ACTH-Secreting Adenoma of Pituitary, Adrenocorticotropin Producing Adenoma of the Pituitary, Adrenocorticotropin Producing Adenoma of the Pituitary Gland, Corticotroph Adenoma, Pituitary Corticotropin Secreting Adenoma, Corticotropinoma, Adrenocorticotropin Secreting Adenoma of the Pituitary, Adrenocorticotropin Secreting Adenoma of the Pituitary Gland, Pituitary Gland ACTH-Secreting Adenoma, Adrenocorticotropin Secreting Pituitary Adenoma, Adrenocorticotropin Producing Pituitary Adenoma, Adrenocorticotropin Secreting Adenoma of Pituitary Gland, Pituitary ACTH Secreting Adenoma, Adrenocorticotropin Secreting Adenoma of Pituitary, Corticotropin Secreting Adenoma of the Pituitary
Parent(s)
Pituitary Gland Adenoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.