Overview

NCI Definition: An acute myeloid leukemia characterized by a predominant immature erythroid population. There are two subtypes recognized: erythroleukemia and pure erythroid leukemia. (WHO, 2001) [1]

Significant Genes in Acute Erythroid Leukemia

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CREBBP +

DEK +

ELL +

ETV6 +

FLT3 +

GLIS2 +

HOXA9 +

KAT6A +

KDM5A +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

NRIP3 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
M6 Acute Myeloid Leukemia, Erythroblastic Leukemia, Acute Erythroblastic Leukemia, FAB M6, AEL, Fab M6, LEUKEMIA, ERYTHROID, MALIGNANT
Parent(s)
Acute Myeloid Leukemia Not Otherwise Specified
Children
Pure Erythroid Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.