Overview

NCI Definition: An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (WHO, 2001) [1]

Acute leukemia of ambiguous lineages most frequently harbor alterations in DNMT3A, RUNX1, TP53, TET2, and BCOR [2].

Most Commonly Altered Genes in Acute Leukemia of Ambiguous Lineage

TP53 Mutation, RUNX1 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and TET2 Mutation are the most common alterations in acute leukemia of ambiguous lineage [2].

Top Alterations in Acute Leukemia of Ambiguous Lineage

Significant Genes in Acute Leukemia of Ambiguous Lineage

ABL1 +

AFF1 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MDM2 +

MDM4 +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NRIP3 +

NUP214 +

PBX1 +

PPM1D +

RPN1 +

SMARCA4 +

SMARCB1 +

TCF3 +

TET2 +

TP53 +

Disease Details

Synonyms
Acute Leukemia of Indeterminate Lineage
Parent(s)
Acute Leukemia
Children
Mixed Phenotype Acute Leukemia and Acute Undifferentiated Leukemia
OncoTree Name
Acute Leukemias of Ambiguous Lineage
OncoTree Code
ALAL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.