Associated Genetic Biomarkers

Overview

NCI Definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. [1]

Significant Genes in Acute Lymphoblastic Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

ATM +

BCL2 +

BCL6 +

BCOR +

BCR +

BIRC3 +

CBFA2T3 +

CBFB +

CEP72 +

CREBBP +

CRLF2 +

CSF1R +

DEK +

DNMT3A +

ELL +

EPOR +

ETV6 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT1 +

FLT3 +

GLIS2 +

HIP1 +

HOXA9 +

HRAS +

IGH +

IKZF1 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KAT6A +

KDM5A +

KIT +

KMT2A +

KRAS +

LYN +

MAF +

MAFB +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MYC +

MYH11 +

NPM1 +

NRAS +

NRIP3 +

NSD1 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

NUP98 +

PBX1 +

PDGFRA +

PDGFRB +

PHF6 +

PML +

PPM1D +

PRDM16 +

RARA +

RET +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SH2B3 +

SMARCA4 +

SMARCB1 +

TCF3 +

TET2 +

TP53 +

TRA +

TRB +

TRD +

TRG +

TYK2 +

WHSC1 +

WT1 +

Disease Details

Synonyms
Acute Lymphoid Leukemia, Precursor Lymphoblastic Leukemia, Acute Lymphocytic Leukemias, Precursor Lymphoblasic Leukemia, Acute lymphoblastic leukemia, NOS, Lymphoblastic Leukemia, ALL, Acute Lymphocytic Leukaemia, Precursor Cell Lymphoblastic Leukemia, LEUKEMIA, LYMPHOBLASTIC, MALIGNANT, ALL - Acute Lymphocytic Leukemia, Acute Lymphocytic Leukemia, Acute Lymphogenous Leukemia
Parent(s)
Precursor Lymphoid Neoplasm
Children
B-Cell Acute Lymphoblastic Leukemia, T-Cell Acute Lymphoblastic Leukemia, and Adult Acute Lymphoblastic Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.