Associated Genetic Biomarkers

Overview

NCI Definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. [1]

Acute lymphoblastic leukemias most frequently harbor alterations in NRAS, CDKN2A, NOTCH1, KRAS, and CDKN2B [2].

Most Commonly Altered Genes in Acute Lymphoblastic Leukemia

NRAS Mutation (somatic), NRAS Mutation (germline), NRAS Mutation, NOTCH1 Mutation, and KRAS Mutation (somatic) are the most common alterations in acute lymphoblastic leukemia [2].

Top Alterations in Acute Lymphoblastic Leukemia

Significant Genes in Acute Lymphoblastic Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

ATM +

BCR +

BIRC3 +

CBFA2T3 +

CBFB +

CBL +

CREBBP +

CRLF2 +

CSF1R +

DEK +

ELL +

EPOR +

ERBB2 +

ERG +

ETV6 +

FGFR3 +

FLT3 +

FUS +

GLIS2 +

HOXA9 +

HRAS +

IGH +

IKZF1 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KAT6A +

KDM5A +

KIT +

KMT2A +

KRAS +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MYC +

MYH11 +

NPM1 +

NRAS +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

PDGFRB +

PML +

PTPN11 +

RARA +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SH2B3 +

TCF3 +

TET2 +

TP53 +

TRA +

TRB +

TRD +

TRG +

WHSC1 +

WT1 +

Disease Details

Synonyms
Acute Lymphocytic Leukemias, LEUKEMIA, LYMPHOBLASTIC, MALIGNANT, Acute lymphoblastic leukemia, NOS, ALL, Acute Lymphoid Leukemia, ALL - Acute Lymphocytic Leukemia, Acute Lymphocytic Leukemia, Precursor Lymphoblastic Leukemia, Precursor Lymphoblasic Leukemia, Acute Lymphogenous Leukemia, Acute Lymphocytic Leukaemia, Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia
Parent(s)
Precursor Lymphoid Neoplasm
Children
Adult Acute Lymphoblastic Leukemia, T-Cell Acute Lymphoblastic Leukemia, and B-Cell Acute Lymphoblastic Leukemia
OncoTree Name
Acute Lymphoid Leukemia
OncoTree Code
ALL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.