Associated Genetic Biomarkers

Overview

NCI Definition: Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. [1]

Acute lymphoblastic leukemias most frequently harbor alterations in WT1, NOTCH1, EZH2, BCORL1, and USP7 [2].

Most Commonly Altered Genes in Acute Lymphoblastic Leukemia

WT1fs, NOTCH1 Mutation, NOTCH1 Missense, EZH2 Mutation, and EZH2 Exon 19 Mutation are the most common alterations in acute lymphoblastic leukemia [2].

Top Alterations in Acute Lymphoblastic Leukemia

Significant Genes in Acute Lymphoblastic Leukemia

ABL1 +

ABL2 +

AFF1 +

ASXL1 +

ATM +

BCL2 +

BCL6 +

BCOR +

BCR +

BIRC3 +

CBFA2T3 +

CBFB +

CBL +

CEP72 +

CREBBP +

CRLF2 +

CSF1R +

DEK +

DNMT3A +

ELL +

EPOR +

ERBB2 +

ETV6 +

FGFR3 +

FLT1 +

FLT3 +

GLIS2 +

HIP1 +

HOXA9 +

HRAS +

IGH +

IKZF1 +

IL7R +

JAK1 +

JAK2 +

JAK3 +

KAT6A +

KDM5A +

KIT +

KMT2A +

KRAS +

MAF +

MAFB +

MDM2 +

MDM4 +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MYC +

MYH11 +

NPM1 +

NRAS +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

PDGFRA +

PDGFRB +

PHF6 +

PML +

PPM1D +

PRDM16 +

PTPN11 +

RARA +

RET +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SH2B3 +

SMARCA4 +

SMARCB1 +

TCF3 +

TET2 +

TP53 +

TRA +

TRB +

TRD +

TRG +

WHSC1 +

WT1 +

Disease Details

Synonyms
Acute lymphoblastic leukemia, NOS, Acute Lymphocytic Leukaemia, LEUKEMIA, LYMPHOBLASTIC, MALIGNANT, Acute Lymphoid Leukemia, ALL - Acute Lymphocytic Leukemia, Acute Lymphocytic Leukemias, Precursor Cell Lymphoblastic Leukemia, Precursor Lymphoblastic Leukemia, Acute Lymphocytic Leukemia, Precursor Lymphoblasic Leukemia, Acute Lymphogenous Leukemia, ALL, Lymphoblastic Leukemia
Parent(s)
Precursor Lymphoid Neoplasm
Children
B-Cell Acute Lymphoblastic Leukemia, Adult Acute Lymphoblastic Leukemia, and T-Cell Acute Lymphoblastic Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.