NCI Definition: Acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage, including monoblasts, promonocytes, and monocytes. Bleeding disorders are common presenting features. [1]

Acute monoblastic and monocytic leukemias most frequently harbor alterations in TET2, FLT3, DNMT3A, NPM1, and IDH2 [2].

Most Commonly Altered Genes in Acute Monoblastic and Monocytic Leukemia

FLT3 Mutation, DNMT3A Mutation, NPM1fs, IDH2 Mutation, and IDH2 Exon 4 Mutation are the most common alterations in acute monoblastic and monocytic leukemia [2].

Top Alterations in Acute Monoblastic and Monocytic Leukemia

Disease Details

Acute Monoblastic Leukemia and Acute Monocytic Leukemia, Acute Myeloid Leukemia M5
Monocytic Leukemia
Acute Monocytic Leukemia
OncoTree Name
Acute Monoblastic/Monocytic Leukemia
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.