Overview

NCI Definition: Acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage, including monoblasts, promonocytes, and monocytes. Bleeding disorders are common presenting features. [1]

Acute monoblastic and monocytic leukemias most frequently harbor alterations in TET2, FLT3, DNMT3A, NPM1, and IDH2 [2].

Most Commonly Altered Genes in Acute Monoblastic and Monocytic Leukemia

FLT3 Mutation, DNMT3A Mutation, NPM1fs, IDH2 Mutation, and IDH2 Exon 4 Mutation are the most common alterations in acute monoblastic and monocytic leukemia [2].

Top Alterations in Acute Monoblastic and Monocytic Leukemia

Disease Details

Synonyms
Acute Myeloid Leukemia M5, Acute Monoblastic Leukemia and Acute Monocytic Leukemia
Parent(s)
Monocytic Leukemia
Children
Acute Monocytic Leukemia
OncoTree Name
Acute Monoblastic/Monocytic Leukemia
OncoTree Code
AMOL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.