Overview

NCI Definition: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome. [1]

Significant Genes in Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

CREBBP +

ETV6 +

HIP1 +

KMT2A +

MECOM +

PDGFRB +

PRDM16 +

RPN1 +

RUNX1 +

Disease Details

Synonyms
Acute Myeloid Leukemia with Multilineage Dysplasia following Myelodysplastic Syndrome, AML/MDS, Acute Myeloid Leukemia (AML) Arising from Previous Myelodysplastic Syndrome
Parent(s)
Secondary Acute Myeloid Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.