Overview

NCI Definition: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome. [1]

Significant Genes in Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

ABL1 +

AFF1 +

ASXL1 +

BCOR +

BCR +

CBL +

CEBPA +

CREBBP +

DEK +

ELL +

ETV6 +

EZH2 +

FLT3 +

HIP1 +

IDH1 +

IDH2 +

KIT +

KMT2A +

KRAS +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NF1 +

NPM1 +

NRAS +

NRIP3 +

NUP214 +

PBX1 +

PDGFRB +

PRDM16 +

PTPN11 +

RIT1 +

RPN1 +

RUNX1 +

SF3B1 +

SRSF2 +

STAG2 +

TCF3 +

TP53 +

U2AF1 +

ZRSR2 +

Disease Details

Synonyms
AML/MDS, Acute Myeloid Leukemia (AML) Arising from Previous Myelodysplastic Syndrome, Acute Myeloid Leukemia with Multilineage Dysplasia following Myelodysplastic Syndrome
Parent(s)
Secondary Acute Myeloid Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.