Overview

NCI Definition: An acute myeloid leukemia developing in patients with a prior history of myelodysplastic syndrome. [1]

Significant Genes in Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome

ABL1 +

AFF1 +

ASXL1 +

BCOR +

BCR +

CBL +

CREBBP +

DEK +

ELL +

ETV6 +

EZH2 +

FLT3 +

HIP1 +

IDH1 +

IDH2 +

KIT +

KMT2A +

KRAS +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NF1 +

NPM1 +

NRAS +

NUP214 +

PBX1 +

PDGFRB +

PRDM16 +

PTPN11 +

RIT1 +

RPN1 +

RUNX1 +

SF3B1 +

SRSF2 +

STAG2 +

TCF3 +

TP53 +

U2AF1 +

ZRSR2 +

Disease Details

Synonyms
Acute Myeloid Leukemia (AML) Arising from Previous Myelodysplastic Syndrome, Acute Myeloid Leukemia with Multilineage Dysplasia following Myelodysplastic Syndrome, AML/MDS
Parent(s)
Secondary Acute Myeloid Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.