Overview

NCI Definition: An acute myeloid leukemia with at least 20% blasts in the bone marrow or blood, and either a previous history of myelodysplastic syndrome, multilineage dysplasia or myelodysplastic syndrome-related cytogenetic abnormalities. There is no history of prior cytotoxic therapy for an unrelated disorder, and there is absence of the cytogenetic abnormalities that are present in acute myeloid leukemia with recurrent genetic abnormalities. [1]

Significant Genes in Acute Myeloid Leukemia with Myelodysplasia-Related Changes

ABL1 +

ASXL1 +

BCR +

CREBBP +

DEK +

ETV6 +

FLT3 +

HIP1 +

KMT2A +

MECOM +

MLF1 +

MLLT3 +

NPM1 +

NUP214 +

PDGFRB +

PRDM16 +

RPN1 +

RUNX1 +

TP53 +

Disease Details

Synonyms
AML with Myelodysplasia-Related Changes
Parent(s)
Acute Myeloid Leukemia
Children
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome
OncoTree Name
AML with Myelodysplasia-Related Changes
OncoTree Code
AMLMRC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.