Fms-related tyrosine kinase 3 (FLT3) is a gene that encodes for a tyrosine kinase that activates pathways in hematopoietic cells (Gene 2013) important in cellular proliferation. The FLT3 protein has an extracellular domain consisting of five immunoglobulin-like domains, a transmembrane domain, a juxtamembrane domain, and two tyrosine kinase domains (Leung, Man, and Kwong 2013).
FLT3 is frequently mutated in acute myeloid leukemia, myelodysplastic syndromes, other hematologic malignancies, and colorectal cancer (COSMIC). Mutations in MDS are skewed towards the highest risk disease (refractory anemia with excess blasts).
Suggested Citation: Wheeler, S., A. Seegmiller, C. Vnencak-Jones, S. Strickland, A. Kim. 2016. FLT3. My Cancer Genome https://www.mycancergenome.org/content/disease/acute-myeloid-leukemia/flt3/?tab=0 (Updated June 17).
Last Updated: June 17, 2016