RNA binding motif protein 15 (RBM15) is a gene that encodes for a protein with repressor function in several signaling pathways (Gene 2013a). In cancer, rearrangements involving RBM15 have been observed in AML. Its role is also being investigated in other cancers.
Megakaryoblastic leukemia (translocation) 1 (MKL1) is a gene that encodes a protein that interacts with myocardin (Gene 2013b). In cancer, rearrangements involving MKL1 have been observed in AML. Its role is also being investigated in other cancers.
The RBM15-MKL1 fusion has been observed in AML, particularly acute megakaryoblastic leukemia.
Suggested Citation: Seegmiller, A., M. Jagasia. 2015. RBM15-MKL1. My Cancer Genome https://www.mycancergenome.org/content/disease/acute-myeloid-leukemia/rbm15-mkl1/?tab=0 (Updated December 4).
Last Updated: December 4, 2015