RBM15-MKL1
RNA binding motif protein 15 (RBM15) is a gene that encodes for a protein with repressor function in several signaling pathways (Gene 2013a). In cancer, rearrangements involving RBM15 have been observed in AML. Its role is also being investigated in other cancers.
Megakaryoblastic leukemia (translocation) 1 (MKL1) is a gene that encodes a protein that interacts with myocardin (Gene 2013b). In cancer, rearrangements involving MKL1 have been observed in AML. Its role is also being investigated in other cancers.
The RBM15-MKL1 fusion has been observed in AML, particularly acute megakaryoblastic leukemia.
Related Pathways
Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S.
Suggested Citation: Seegmiller, A., M. Jagasia. 2015. RBM15-MKL1. My Cancer Genome https://www.mycancergenome.org/content/disease/acute-myeloid-leukemia/rbm15-mkl1/?tab=0 (Updated December 4).
Last Updated: December 4, 2015
RBM15-MKL1 Fusion Gene in Acute Myeloid Leukemia
The RBM15-MKL1 fusion gene, t(1;22)(p13;q13), is rarely observed in AML but is associated with megakaryoblastic leukemia. The fusion protein has been shown in preclinical studies to disrupt Notch signaling and cytokine signaling (Mercher et al. 2009).
Contributors: Adam Seegmiller, M.D., Ph.D., Madan Jagasia, M.B.B.S., M.S., Scott Wheeler, Ph.D. (through June 2014), Cindy L. Vnencak-Jones, Ph.D.
Suggested Citation: Seegmiller, A., M. Jagasia, S. Wheeler, C. Vnencak-Jones. 2013. RBM15-MKL1 Fusion Gene in Acute Myeloid Leukemia. My Cancer Genome https://www.mycancergenome.org/content/disease/acute-myeloid-leukemia/rbm15-mkl1/ (Updated September 9).
Last Updated: September 9, 2013
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