Ribophorin I (RPN1) is a gene that encodes a membrane protein of the rough endoplasmic reticulum that is a component of an N-oligosaccharyl transferase complex (Gene 2013a). In cancer, rearrangements involving RPN1 have been observed in AML.
MDS1 and EVI1 complex locus (MECOM, also known as EVI1) is a gene that encodes a transcriptional regulator protein (Gene 2013b). In cancer, rearrangements involving EVI1 have been observed in AML. Its role is also being investigated in MDS and other cancers.
The RPN1-EVI1 fusion has been observed in AML and CML (Lee et al. 2010).
Suggested Citation: Seegmiller, A., M. Jagasia. 2013. RPN1-EVI1 (RPN1-MECOM). My Cancer Genome https://www.mycancergenome.org/content/disease/acute-myeloid-leukemia/rpn1-evi1/?tab=0 (Updated June 4).
Last Updated: June 4, 2013