Overview

NCI Definition: An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. (WHO, 2001) [1]

Acute myelomonocytic leukemias most frequently harbor alterations in DNMT3A, NPM1, FLT3, TET2, and NRAS [2].

DNMT3A Mutation, NPM1fs, FLT3 Mutation, TET2 Mutation, and FLT3 Exon 14 Mutation are the most common alterations in acute myelomonocytic leukemia [2].

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.