NCI Definition: An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. (WHO, 2001) [1]

Acute myelomonocytic leukemias most frequently harbor alterations in DNMT3A, NPM1, FLT3, TET2, and NRAS [2].

Most Commonly Altered Genes in Acute Myelomonocytic Leukemia

DNMT3A Mutation, NPM1fs, FLT3 Mutation, TET2 Mutation, and FLT3 Exon 14 Mutation are the most common alterations in acute myelomonocytic leukemia [2].

Top Alterations in Acute Myelomonocytic Leukemia

Disease Details

Acute Myelomonocytic Leukemia (FAB Type M4), Acute M4 Myeloid Leukemia, AMML
Acute Myeloid Leukemia Not Otherwise Specified
OncoTree Name
Acute Myelomonocytic Leukemia
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.