Overview

NCI Definition: A rare acute leukemia of ambiguous lineage in which the blasts do not express markers specific to myeloid or lymphoid lineage. [1]

Acute undifferentiated leukemias most frequently harbor alterations in U2AF1, TP53, PHF6, PDGFRA, and NOTCH1 [2].

Most Commonly Altered Genes in Acute Undifferentiated Leukemia

U2AF1 R35L, U2AF1 Mutation, U2AF1 Exon 2 Mutation, TP53 c.217-c.1178 Missense, and TP53 Mutation are the most common alterations in acute undifferentiated leukemia [2].

Top Alterations in Acute Undifferentiated Leukemia

Significant Genes in Acute Undifferentiated Leukemia

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CREBBP +

DEK +

ELL +

ETV6 +

FLT3 +

GLIS2 +

HOXA9 +

IKZF1 +

KAT6A +

KDM5A +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

NPM1 +

NRIP3 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
Undifferentiated Acute Leukemia, Stem Cell Acute Leukemia, Acute Leukemia, NOS, Stem Cell Leukemia, Leukemia Stem Cell, Acute Leukemia, Not Otherwise Specified
Parent(s)
Acute Leukemia of Ambiguous Lineage
OncoTree Name
Acute Undifferentiated Leukemia
OncoTree Code
AUL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.