NCI Definition: An adenocarcinoma which has metastasized from an unknown primary anatomic site. [1]

Adenocarcinoma of unknown primarys most frequently harbor alterations in TP53, KRAS, CDKN2A, SMAD4, and ARID1A [2].

Most Commonly Altered Genes in Adenocarcinoma of Unknown Primary

TP53 Mutation, KRAS Mutation, KRAS Exon 2 Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in adenocarcinoma of unknown primary [2].

Top Alterations in Adenocarcinoma of Unknown Primary

Disease Details

Unknown primary adenocarcinoma, Unknown primary, adenocarcinoma
Carcinoma of Unknown Primary
Serous Adenocarcinoma of Unknown Primary
OncoTree Name
Adenocarcinoma, NOS
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.