Overview

NCI Definition: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [1]

Adenocarcinomas most frequently harbor alterations in TP53, KRAS, APC, PIK3CA, and EGFR [2].

Most Commonly Altered Genes in Adenocarcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in adenocarcinoma [2].

Top Alterations in Adenocarcinoma

Significant Genes in Adenocarcinoma

KRAS +

Disease Details

Synonyms
Invasive Adenocarcinoma, Metastatic adenocarcinoma, Poorly Differentiated Adenocarcinoma, Invasive Poorly Differentiated Adenocarcinoma, Adenocarcinoma, NOS, ADENOCARCINOMA, MALIGNANT
Parent(s)
Carcinoma
Children
Mesonephric Adenocarcinoma, Combined Hepatocellular Carcinoma and Cholangiocarcinoma, Adenocarcinoma of Unknown Primary, Adenocarcinoma of the Gastroesophageal Junction, Signet Ring Cell Carcinoma, Cervical Adenocarcinoma, Mucinous Adenocarcinoma, Basophilic Adenocarcinoma, Papillary Adenocarcinoma, Ampulla of Vater Adenocarcinoma, Colorectal Adenocarcinoma, Lung Adenocarcinoma, Gastric Adenocarcinoma, Renal Pelvis Adenocarcinoma, Thyroid Gland Adenocarcinoma, Gallbladder Adenocarcinoma, Cystadenocarcinoma, Bladder Adenocarcinoma, Ovarian Adenocarcinoma, Hepatocellular Carcinoma, Pituitary Gland Carcinoma, Fallopian Tube Adenocarcinoma, Villous Adenocarcinoma, Parathyroid Gland Carcinoma, Prostate Adenocarcinoma, Renal Cell Carcinoma, Small Intestinal Adenocarcinoma, Breast Adenocarcinoma, Esophageal Adenocarcinoma, Serous Adenocarcinoma, Ureter Adenocarcinoma, Tubular Adenocarcinoma, Endometrial Adenocarcinoma, Endometrioid Adenocarcinoma, Appendix Adenocarcinoma, Intestinal Type Adenocarcinoma, Scirrhous Adenocarcinoma, Sinonasal Adenocarcinoma, Sebaceous Carcinoma, Salivary Gland Adenocarcinoma, Vulvar/Vaginal Adenocarcinoma, Clear Cell Adenocarcinoma, Anal Adenocarcinoma, Bile Duct Adenocarcinoma, Paget Disease, Primary Peritoneal Adenocarcinoma, Seminal Vesicle Adenocarcinoma, Adrenal Cortex Carcinoma, Cecum Adenocarcinoma, and Sweat Gland Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.