NCI Definition: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [1]

Adenocarcinomas most frequently harbor alterations in TP53, KRAS, APC, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in adenocarcinoma [2].

Top Alterations in Adenocarcinoma

Disease Details

Sweat Gland Carcinoma, Cystadenocarcinoma, Pituitary Gland Carcinoma, Mesonephric Adenocarcinoma, Endometrioid Adenocarcinoma, Renal Cell Carcinoma, Cecum Adenocarcinoma, Intestinal Type Adenocarcinoma, Sebaceous Carcinoma, Gallbladder Adenocarcinoma, Papillary Adenocarcinoma, Signet Ring Cell Carcinoma, Scirrhous Adenocarcinoma, Tubular Adenocarcinoma, Apocrine/Eccrine Sweat Gland Carcinoma, Paget Disease, Clear Cell Adenocarcinoma, Thyroid Gland Adenocarcinoma, Villous Adenocarcinoma, Colorectal Adenocarcinoma, Adenocarcinoma of Unknown Primary, Mucinous Adenocarcinoma, Basophilic Adenocarcinoma, Vulvar/Vaginal Adenocarcinoma, and Small Intestinal Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.