NCI Definition: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [1]

Adenocarcinomas most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and BRAF [2].

Most Commonly Altered Genes in Adenocarcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, APC Mutation, and KRAS Mutation are the most common alterations in adenocarcinoma [2].

Top Alterations in Adenocarcinoma

Significant Genes in Adenocarcinoma


MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Mesonephric Adenocarcinoma, Ovarian Adenocarcinoma, Sweat Gland Carcinoma, Thyroid Gland Adenocarcinoma, Fallopian Tube Adenocarcinoma, Apocrine/Eccrine Sweat Gland Carcinoma, Signet Ring Cell Carcinoma, Intestinal Type Adenocarcinoma, Cystadenocarcinoma, Gallbladder Adenocarcinoma, Seminal Vesicle Adenocarcinoma, Adenocarcinoma of the Gastroesophageal Junction, Bile Duct Adenocarcinoma, Ureter Adenocarcinoma, Colorectal Adenocarcinoma, Adenocarcinoma of Unknown Primary, Tubular Adenocarcinoma, Vulvar/Vaginal Adenocarcinoma, Villous Adenocarcinoma, Papillary Adenocarcinoma, Paget Disease, Renal Cell Carcinoma, Cervical Adenocarcinoma, Bladder Adenocarcinoma, Small Intestinal Adenocarcinoma, Cecum Adenocarcinoma, Mucinous Adenocarcinoma, Pituitary Gland Carcinoma, Endometrioid Adenocarcinoma, Renal Pelvis Adenocarcinoma, Sebaceous Carcinoma, Serous Adenocarcinoma, Salivary Gland Adenocarcinoma, Clear Cell Adenocarcinoma, Scirrhous Adenocarcinoma, Gastric Adenocarcinoma, and Basophilic Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.