NCI Definition: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [1]

Adenocarcinomas most frequently harbor alterations in TP53, KRAS, APC, PIK3CA, and EGFR [2].

Most Commonly Altered Genes in Adenocarcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in adenocarcinoma [2].

Top Alterations in Adenocarcinoma

Significant Genes in Adenocarcinoma


UGT1A1 +

Disease Details

Invasive Poorly Differentiated Adenocarcinoma, Metastatic adenocarcinoma, Adenocarcinoma, NOS, ADENOCARCINOMA, MALIGNANT, Poorly Differentiated Adenocarcinoma, Invasive Adenocarcinoma
Appendix Adenocarcinoma, Prostate Adenocarcinoma, Scirrhous Adenocarcinoma, Sebaceous Carcinoma, Fallopian Tube Adenocarcinoma, Endometrioid Adenocarcinoma, Clear Cell Adenocarcinoma, Hepatocellular Carcinoma, Breast Adenocarcinoma, Bladder Adenocarcinoma, Lung Adenocarcinoma, Small Intestinal Adenocarcinoma, Bile Duct Adenocarcinoma, Anal Adenocarcinoma, Basophilic Adenocarcinoma, Combined Hepatocellular Carcinoma and Cholangiocarcinoma, Signet Ring Cell Carcinoma, Primary Peritoneal Adenocarcinoma, Parathyroid Gland Carcinoma, Ampulla of Vater Adenocarcinoma, Mesonephric Adenocarcinoma, Salivary Gland Adenocarcinoma, Renal Cell Carcinoma, Intestinal Type Adenocarcinoma, Endometrial Adenocarcinoma, Ureter Adenocarcinoma, Renal Pelvis Adenocarcinoma, Vulvar/Vaginal Adenocarcinoma, Villous Adenocarcinoma, Gallbladder Adenocarcinoma, Gastric Adenocarcinoma, Cystadenocarcinoma, Tubular Adenocarcinoma, Adrenal Cortex Carcinoma, Cervical Adenocarcinoma, Paget Disease, Adenocarcinoma of Unknown Primary, Papillary Adenocarcinoma, Thyroid Gland Adenocarcinoma, Adenocarcinoma of the Gastroesophageal Junction, Sweat Gland Carcinoma, Colorectal Adenocarcinoma, Cecum Adenocarcinoma, Pituitary Gland Carcinoma, Seminal Vesicle Adenocarcinoma, Esophageal Adenocarcinoma, Sinonasal Adenocarcinoma, Ovarian Adenocarcinoma, Mucinous Adenocarcinoma, and Serous Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.