Overview

NCI Definition: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [1]

Adenocarcinomas most frequently harbor alterations in TP53, KRAS, APC, PIK3CA, and EGFR [2].

Most Commonly Altered Genes in Adenocarcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in adenocarcinoma [2].

Top Alterations in Adenocarcinoma

Significant Genes in Adenocarcinoma

KRAS +

UGT1A1 +

Disease Details

Synonyms
Adenocarcinoma, NOS, Invasive Adenocarcinoma, ADENOCARCINOMA, MALIGNANT, Poorly Differentiated Adenocarcinoma, Metastatic adenocarcinoma, Invasive Poorly Differentiated Adenocarcinoma
Parent(s)
Carcinoma
Children
Ureter Adenocarcinoma, Lung Adenocarcinoma, Gallbladder Adenocarcinoma, Adrenal Cortex Carcinoma, Hepatocellular Carcinoma, Breast Adenocarcinoma, Combined Hepatocellular Carcinoma and Cholangiocarcinoma, Scirrhous Adenocarcinoma, Renal Pelvis Adenocarcinoma, Bladder Adenocarcinoma, Colorectal Adenocarcinoma, Adenocarcinoma of Unknown Primary, Paget Disease, Gastric Adenocarcinoma, Endometrioid Adenocarcinoma, Serous Adenocarcinoma, Cystadenocarcinoma, Seminal Vesicle Adenocarcinoma, Bile Duct Adenocarcinoma, Sweat Gland Carcinoma, Fallopian Tube Adenocarcinoma, Sebaceous Carcinoma, Pituitary Gland Carcinoma, Esophageal Adenocarcinoma, Cervical Adenocarcinoma, Prostate Adenocarcinoma, Ampulla of Vater Adenocarcinoma, Villous Adenocarcinoma, Thyroid Gland Adenocarcinoma, Mesonephric Adenocarcinoma, Adenocarcinoma of the Gastroesophageal Junction, Endometrial Adenocarcinoma, Salivary Gland Adenocarcinoma, Parathyroid Gland Carcinoma, Sinonasal Adenocarcinoma, Clear Cell Adenocarcinoma, Appendix Adenocarcinoma, Anal Adenocarcinoma, Mucinous Adenocarcinoma, Primary Peritoneal Adenocarcinoma, Signet Ring Cell Carcinoma, Papillary Adenocarcinoma, Renal Cell Carcinoma, Cecum Adenocarcinoma, Small Intestinal Adenocarcinoma, Intestinal Type Adenocarcinoma, Tubular Adenocarcinoma, Basophilic Adenocarcinoma, Ovarian Adenocarcinoma, and Vulvar/Vaginal Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.