Overview

NCI Definition: A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [1]

Adenocarcinomas most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and BRAF [2].

Most Commonly Altered Genes in Adenocarcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, APC Mutation, and KRAS Mutation are the most common alterations in adenocarcinoma [2].

Top Alterations in Adenocarcinoma

Significant Genes in Adenocarcinoma

KRAS +

Disease Details

Synonyms
ADENOCARCINOMA, MALIGNANT, Adenocarcinoma, NOS
Parent(s)
Carcinoma
Children
Gallbladder Adenocarcinoma, Salivary Gland Adenocarcinoma, Cystadenocarcinoma, Colorectal Adenocarcinoma, Bile Duct Adenocarcinoma, Thyroid Gland Adenocarcinoma, Intestinal Type Adenocarcinoma, Basophilic Adenocarcinoma, Signet Ring Cell Carcinoma, Renal Pelvis Adenocarcinoma, Mesonephric Adenocarcinoma, Fallopian Tube Adenocarcinoma, Ureter Adenocarcinoma, Gastric Adenocarcinoma, Vulvar/Vaginal Adenocarcinoma, Adenocarcinoma of the Gastroesophageal Junction, Bladder Adenocarcinoma, Endometrioid Adenocarcinoma, Apocrine/Eccrine Sweat Gland Carcinoma, Scirrhous Adenocarcinoma, Adenocarcinoma of Unknown Primary, Sebaceous Carcinoma, Cervical Adenocarcinoma, Seminal Vesicle Adenocarcinoma, Sweat Gland Carcinoma, Ovarian Adenocarcinoma, Cecum Adenocarcinoma, Serous Adenocarcinoma, Mucinous Adenocarcinoma, Small Intestinal Adenocarcinoma, Renal Cell Carcinoma, Paget Disease, Tubular Adenocarcinoma, Papillary Adenocarcinoma, Villous Adenocarcinoma, Pituitary Gland Carcinoma, and Clear Cell Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.