NCI Definition: A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma. 
Adnexal carcinomas most frequently harbor alterations in TP53, ROS1, PTCH1, NOTCH1, and KMT2C .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 7 Mutation, and TP53 Exon 5 Mutation are the most common alterations in adnexal carcinoma .
There are 2 clinical trials for adnexal carcinoma, of which 2 are open and 0 are completed or closed. Of the trials that contain adnexal carcinoma as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
Xmab20717 and nivolumab are the most common interventions in adnexal carcinoma clinical trials.
Significant Genes in Adnexal Carcinoma
POLE is an inclusion eligibility criterion in 1 clinical trial for adnexal carcinoma, of which 1 is open and 0 are closed. Of the trial that contains POLE status and adnexal carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.