NCI Definition: A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma. [1]

Adnexal carcinomas most frequently harbor alterations in TP53, ROS1, PTCH1, NOTCH1, and KMT2C [2].

Most Commonly Altered Genes in Adnexal Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 7 Mutation, and TP53 Exon 5 Mutation are the most common alterations in adnexal carcinoma [2].

Top Alterations in Adnexal Carcinoma

Significant Genes in Adnexal Carcinoma


Disease Details

Carcinoma of Adnexa, CARCINOMA, ADNEXAL, MALIGNANT, Skin Appendage Carcinoma, Carcinoma of Skin Appendage, Skin Adnexal Carcinoma
Skin Carcinoma
Sebaceous Carcinoma and Sweat Gland Carcinoma
OncoTree Name
Skin Adnexal Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.