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Adrenal Gland Pheochromocytoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present. [1]

Clinical Trials

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Significant Genes in Adrenal Gland Pheochromocytoma

RET +

SDHB +

SDHC +

VHL +

Disease Details

Synonyms
Adrenal Gland Chromaffin Paraganglioma, Adrenal Gland Paraganglioma, PCC, Pheochromocytoma, Adrenal Pheochromocytoma, Intraadrenal Paraganglioma, PHEOCHROMOCYTOMA, UNDETERMINED, Adrenal Medullary Paraganglioma, Pheochromocytoma (adrenal), Adrenal Gland Chromaffinoma, Chromaffin Paraganglioma of the Adrenal Gland, Phaeochromocytoma, Adrenal Medullary Pheochromocytoma
Parent(s)
Sympathetic Paraganglioma
OncoTree Name
Pheochromocytoma
OncoTree Code
PHC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.