Diseases /
Adrenal Gland Pheochromocytoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present. [1]
Adrenal gland pheochromocytomas most frequently harbor alterations in VHL, ATRX, KMT2D, BRCA2, and NF1 [2].
VHL Mutation, ATRX Mutation, KMT2D Mutation, BRCA2 Mutation, and NF1 Nonsense are the most common alterations in adrenal gland pheochromocytoma [2].
Clinical Trials
Significant Genes in Adrenal Gland Pheochromocytoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.
