Overview

NCI Definition: A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa. [1]

Adult T-cell leukemia/lymphomas most frequently harbor alterations in WHSC1, TP53, SOCS1, FGFR3, and VHL [2].

Most Commonly Altered Genes in Adult T-Cell Leukemia/Lymphoma

TP53 Mutation, SOCS1 Loss, WHSC1 Loss, WHSC1 Amplification, and VHL Mutation are the most common alterations in adult T-cell leukemia/lymphoma [2].

Top Alterations in Adult T-Cell Leukemia/Lymphoma

Significant Genes in Adult T-Cell Leukemia/Lymphoma

ABL1 +

AFF1 +

BCR +

CBFB +

DEK +

ELL +

FLT3 +

KIT +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NRIP3 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

Disease Details

Synonyms
ATLL, Adult T Cell Lymphoma/Leukemia, HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia, Adult T-Cell Lymphoma/Leukemia, HTLV-I Associated Adult T-Cell Leukemia/Lymphoma
Parent(s)
Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
Children
Lymphomatous Adult T-Cell Leukemia/Lymphoma and Smoldering Adult T-Cell Leukemia/Lymphoma
OncoTree Name
Adult T-Cell Leukemia/Lymphoma
OncoTree Code
ATLL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.