Diseases /
Adult T-Cell Leukemia/Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1). Adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa. [1]
Adult T-cell leukemia/lymphomas most frequently harbor alterations in WHSC1, TP53, SOCS1, FGFR3, and VHL [2].
TP53 Mutation, SOCS1 Loss, WHSC1 Loss, WHSC1 Amplification, and VHL Mutation are the most common alterations in adult T-cell leukemia/lymphoma [2].
Clinical Trials
Significant Genes in Adult T-Cell Leukemia/Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.