Associated Genetic Biomarkers

Overview

NCI Definition: A non-Hodgkin lymphoma with an aggressive clinical course. Representative examples include Burkitt lymphoma, mantle cell lymphoma, and angioimmunoblastic T-cell lymphoma. [1]

Aggressive non-hodgkin lymphomas most frequently harbor alterations in TET2, TP53, ATM, KMT2D, and DNMT3A [2].

Most Commonly Altered Genes in Aggressive Non-Hodgkin Lymphoma

ATM Mutation, TP53 Mutation, TET2 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in aggressive non-hodgkin lymphoma [2].

Top Alterations in Aggressive Non-Hodgkin Lymphoma

Significant Genes in Aggressive Non-Hodgkin Lymphoma

MECOM +

MLF1 +

NPM1 +

RPN1 +

Disease Details

Parent(s)
Non-Hodgkin Lymphoma by Clinical Course
Children
Grade 3 Follicular Lymphoma, Enteropathy-Associated T-Cell Lymphoma, Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma, Peripheral T-Cell Lymphoma, Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma, Mantle Cell Lymphoma, Diffuse Large B-Cell Lymphoma Activated B-Cell Type, Burkitt-Like Lymphoma with 11q Aberration, Adult T-Cell Leukemia/Lymphoma, Primary Cutaneous Gamma-Delta T-Cell Lymphoma, Angioimmunoblastic T-Cell Lymphoma, Nasal Type Extranodal NK/T-Cell Lymphoma, B-Cell Lymphoblastic Lymphoma, Sezary Syndrome, Hepatosplenic T-Cell Lymphoma, Burkitt Lymphoma, Peripheral T-Cell Lymphoma, Not Otherwise Specified, T-Cell Lymphoblastic Lymphoma, and Anaplastic Large Cell Lymphoma, ALK-Negative

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.