Ampulla of Vater Pancreatobiliary Type Adenocarcinoma
NCI Definition: An invasive adenocarcinoma that arises from the ampulla of Vater. It is characterized by the presence of malignant cells that resemble the malignant cells of the pancreatic ductal or extrahepatic bile duct carcinomas. 
Ampulla of vater pancreatobiliary type adenocarcinomas most frequently harbor alterations in KRAS, TP53, CDKN2A, SMAD4, and CDKN2B .
KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in ampulla of vater pancreatobiliary type adenocarcinoma .
There is 1 clinical trial for ampulla of vater pancreatobiliary type adenocarcinoma, of which 1 is open and 0 are completed or closed. Of the trial that contains ampulla of vater pancreatobiliary type adenocarcinoma as an inclusion criterion, 1 is early phase 1 (1 open).
Stereotactic body radiation therapy is the most common intervention in ampulla of vater pancreatobiliary type adenocarcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.