NCI Definition: An invasive adenocarcinoma that arises from the ampulla of Vater. It is characterized by the presence of malignant cells that resemble the malignant cells of the pancreatic ductal or extrahepatic bile duct carcinomas. [1]

Ampulla of vater pancreatobiliary type adenocarcinomas most frequently harbor alterations in KRAS, TP53, CDKN2A, SMAD4, and CDKN2B [2].

Most Commonly Altered Genes in Ampulla of Vater Pancreatobiliary Type Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in ampulla of vater pancreatobiliary type adenocarcinoma [2].

Top Alterations in Ampulla of Vater Pancreatobiliary Type Adenocarcinoma

Disease Details

Ampulla of Vater Adenocarcinoma
OncoTree Name
Pancreatobiliary Ampullary Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.