Anal Intraepithelial Neoplasia
Associated Genetic Biomarkers
NCI Definition: A precancerous neoplastic intraepithelial process involving either the squamous and transitional zones of the anal canal or the perianal skin (anal margin). 
There are 2 clinical trials for anal intraepithelial neoplasia, of which 1 is open and 1 is completed or closed. Of the trials that contain anal intraepithelial neoplasia as an inclusion criterion, 2 are phase 1 (1 open).
CDKN2A and HPV are the most frequent gene inclusion criteria for anal intraepithelial neoplasia clinical trials .
Aminolevulinic acid, photodynamic therapy, and vitamin d3 are the most common interventions in anal intraepithelial neoplasia clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.