Associated Genetic Biomarkers
NCI Definition: A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma. 
Anal neoplasms most frequently harbor alterations in PIK3CA, KMT2D, SF3B1, TP53, and KIT .
PIK3CA Mutation, KMT2D Mutation, SF3B1 Mutation, SF3B1 Exon 14 Mutation, and SF3B1 Codon 625 Missense are the most common alterations in anal neoplasm .
There is 1 clinical trial for anal neoplasm, of which 0 are open and 1 is completed or closed. Of the trial that contains anal neoplasm as an inclusion criterion, 1 is phase 4 (0 open).
Hpv vaccine and placebo are the most common interventions in anal neoplasm clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.