NCI Definition: A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma. 
Anal neoplasms most frequently harbor alterations in PIK3CA, KMT2D, FBXW7, SOX2, and BCL6 .
PIK3CA Mutation, PIK3CA Codon 545 Missense, PIK3CA E545K, KMT2D Mutation, and SOX2 Amplification are the most common alterations in anal neoplasm .
There is 1 clinical trial for anal neoplasm, of which 1 is open and 0 are completed or closed. Of the trial that contains anal neoplasm as an inclusion criterion, 1 is phase 4 (1 open).
Human papilloma virus vaccine and placebo are the most common interventions in anal neoplasm clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.