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Anal Squamous Cell Carcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC. [1]

Clinical Trials

View Clinical Trials for Anal Squamous Cell Carcinoma

Disease Details

Synonyms
Squamous Cell Anal Carcinoma, Epidermoid Carcinoma of Anus, Epidermoid Anal Carcinoma, Anus squamous cell carcinoma, Epidermoid Carcinoma of the Anus, Squamous Cell Carcinoma of the Anus, Squamous Cell Carcinoma of Anus, Squamous cell carcinoma - anus
Parent(s)
Squamous Cell Carcinoma
Children
Anal Margin Squamous Cell Carcinoma, Anal Canal Squamous Cell Carcinoma, Anal Verrucous Carcinoma, and Anal Basaloid Carcinoma
OncoTree Name
Anal Squamous Cell Carcinoma
OncoTree Code
ANSC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.