Overview

NCI Definition: An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity. [1]

Anaplastic oligoastrocytomas most frequently harbor alterations in IDH1, TP53, ATRX, TERT, and SOX2 [2].

Most Commonly Altered Genes in Anaplastic Oligoastrocytoma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in anaplastic oligoastrocytoma [2].

Top Alterations in Anaplastic Oligoastrocytoma

Significant Genes in Anaplastic Oligoastrocytoma

ATRX +

EGFR +

H3F3A +

TP53 +

Disease Details

Synonyms
Anaplastic Mixed Glioma, WHO Grade III Mixed Glioma
Parent(s)
Mixed Glioma
OncoTree Name
Anaplastic Oligoastrocytoma
OncoTree Code
AOAST

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.