NCI Definition: An oligoastrocytoma characterized by the presence of increased cellularity, nuclear atypia, pleomorphism, and high mitotic activity. [1]

Anaplastic oligoastrocytomas most frequently harbor alterations in IDH1, TP53, ATRX, TERT, and SOX2 [2].

Most Commonly Altered Genes in Anaplastic Oligoastrocytoma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in anaplastic oligoastrocytoma [2].

Top Alterations in Anaplastic Oligoastrocytoma

Significant Genes in Anaplastic Oligoastrocytoma



H3F3A +

TP53 +

Disease Details

Anaplastic Mixed Glioma, WHO Grade III Mixed Glioma
Mixed Glioma
OncoTree Name
Anaplastic Oligoastrocytoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.