Overview

Anaplastic oligodendrogliomas most frequently harbor alterations in IDH1, PIK3CA, NOTCH1, IDH2, and SETD2 [2].

Most Commonly Altered Genes in Anaplastic Oligodendroglioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, PIK3CA Mutation, and NOTCH1 Mutation are the most common alterations in anaplastic oligodendroglioma [2].

Top Alterations in Anaplastic Oligodendroglioma

Significant Genes in Anaplastic Oligodendroglioma

APC +

CDK6 +

CTDNEP1 +

CTNNB1 +

DDX3X +

EGFR +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

GLI2 +

H3F3A +

IDH1 +

IDH2 +

KDM6A +

KMT2C +

KMT2D +

LRP1B +

MDM4 +

MYC +

MYCL +

MYCN +

OTX2 +

PPM1D +

PTCH1 +

PTEN +

PVT1 +

RELA +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SUFU +

TERT +

TP53 +

YAP1 +

ZMYM3 +

Disease Details

Parent(s)
Oligodendroglioma
Children
Anaplastic Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted
OncoTree Name
Anaplastic Oligodendroglioma
OncoTree Code
AODG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.