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Angiosarcoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, it is characterized by frequently open vascular anastomosing and branching channels. The malignant cells that line the vascular channels are spindle or epithelioid and often display hyperchromatic nuclei. Angiosarcomas most frequently occur in the skin and breast. Patients with long-standing lymphedema are at increased risk of developing angiosarcoma. [1]

Clinical Trials

View Clinical Trials for Angiosarcoma

Significant Genes in Angiosarcoma

CD274 +

PIK3CA +

PTEN +

Disease Details

Synonyms
Hemangiosarcoma, Malignant Angioendothelioma, HEMANGIOSARCOMA, MALIGNANT, Malignant Hemangioendothelioma
Parent(s)
Sarcoma
Children
Central Nervous System Angiosarcoma, Gallbladder Angiosarcoma, Thyroid Gland Angiosarcoma, Skin Angiosarcoma, Breast Angiosarcoma, Superior Vena Cava Angiosarcoma, Ovarian Angiosarcoma, Aortic Angiosarcoma, Prostate Angiosarcoma, Mediastinal Angiosarcoma, Childhood Angiosarcoma, Liver Angiosarcoma, Conventional Angiosarcoma, Pulmonary Artery Angiosarcoma, Bone Angiosarcoma, and Splenic Angiosarcoma
OncoTree Name
Angiosarcoma
OncoTree Code
ANGS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.