Overview

NCI Definition: Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors. [1]

Significant Genes in Aplastic Anemia

ABL1 +

AFF1 +

ASXL1 +

BCR +

CBFB +

DEK +

DNMT3A +

ELL +

FGFR3 +

FLT3 +

IGH +

KIT +

KMT2A +

MAF +

MAFB +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NUP214 +

PBX1 +

PHF6 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TET2 +

TP53 +

WHSC1 +

Disease Details

Parent(s)
Anemia
Children
Sideroblastic Anemia, Leukoerythroblastosis, and Pure Red Cell Aplasia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.