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Appendix Mucinous Adenocarcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma arising from the appendix, characterized by the presence of mucinous stroma formation. [1]

Appendix mucinous adenocarcinomas most frequently harbor alterations in KRAS, GNAS, TP53, SMAD4, and TGFBR2 [2].

Most Commonly Altered Genes in Appendix Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, GNAS Mutation, and KRAS G12D are the most common alterations in appendix mucinous adenocarcinoma [2].

Top Alterations in Appendix Mucinous Adenocarcinoma

Clinical Trials

View Clinical Trials for Appendix Mucinous Adenocarcinoma

Disease Details

Synonyms
Appendiceal Mucinous Adenocarcinoma, Mucinous Adenocarcinoma of Appendix, Mucinous Adenocarcinoma of the Appendix, Appendix mucinous neoplasm (NOS)
Parent(s)
Mucinous Adenocarcinoma
Children
Low-Grade Appendiceal Mucinous Neoplasm and Appendix Mucinous Cystadenocarcinoma
OncoTree Name
Mucinous Adenocarcinoma of the Appendix
OncoTree Code
MAAP

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.