NCI Definition: An adenocarcinoma arising from the appendix, characterized by the presence of mucinous stroma formation. [1]

Appendix mucinous adenocarcinomas most frequently harbor alterations in KRAS, GNAS, TP53, SMAD4, and TGFBR2 [2].

Most Commonly Altered Genes in Appendix Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, GNAS Mutation, and KRAS G12D are the most common alterations in appendix mucinous adenocarcinoma [2].

Top Alterations in Appendix Mucinous Adenocarcinoma

Disease Details

Appendiceal Mucinous Adenocarcinoma, Mucinous Adenocarcinoma of Appendix, Mucinous Adenocarcinoma of the Appendix, Appendix mucinous neoplasm (NOS)
Mucinous Adenocarcinoma
Low-Grade Appendiceal Mucinous Neoplasm and Appendix Mucinous Cystadenocarcinoma
OncoTree Name
Mucinous Adenocarcinoma of the Appendix
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.