NCI Definition: An adenocarcinoma arising from the appendix, characterized by the presence of mucinous stroma formation. [1]

Appendix mucinous adenocarcinomas most frequently harbor alterations in KRAS, GNAS, TP53, SMAD4, and TGFBR2 [2].

Most Commonly Altered Genes in Appendix Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, GNAS Mutation, and KRAS G12D are the most common alterations in appendix mucinous adenocarcinoma [2].

Top Alterations in Appendix Mucinous Adenocarcinoma

Disease Details

Appendix mucinous neoplasm (NOS), Appendiceal Mucinous Adenocarcinoma, Mucinous Adenocarcinoma of Appendix, Mucinous Adenocarcinoma of the Appendix
Mucinous Adenocarcinoma
Appendix Mucinous Cystadenocarcinoma and Low-Grade Appendiceal Mucinous Neoplasm
OncoTree Name
Mucinous Adenocarcinoma of the Appendix
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.