Overview

NCI Definition: A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma. [1]

Astrocytomas most frequently harbor alterations in TP53, IDH1, ATRX, BRAF, and EGFR [2].

Most Commonly Altered Genes in Astrocytoma

TP53 Mutation, IDH1 Mutation, IDH1 Codon 132 Missense, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in astrocytoma [2].

Top Alterations in Astrocytoma

Significant Genes in Astrocytoma

ATRX +

EGFR +

ERBB2 +

ERBB4 +

IDH1 +

IDH2 +

TERT +

Disease Details

Synonyms
High-grade astrocytoma, WHO grade IV, ASTROCYTOMA, UNDETERMINED
Parent(s)
Astrocytic Tumor
Children
Adult Astrocytic Tumor, Childhood Astrocytic Tumor, Diffuse Astrocytoma, Subependymal Giant Cell Astrocytoma, Pleomorphic Xanthoastrocytoma, Pilomyxoid Astrocytoma, Pilocytic Astrocytoma, Brain Astrocytoma, Anaplastic Astrocytoma, and Anaplastic Pleomorphic Xanthoastrocytoma
OncoTree Name
Astrocytoma
OncoTree Code
ASTR

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.