Overview

NCI Definition: A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma. [1]

Significant Genes in Astrocytoma

ATRX +

EGFR +

ERBB2 +

ERBB4 +

IDH1 +

IDH2 +

TERT +

Disease Details

Synonyms
High-grade astrocytoma, WHO grade IV, ASTROCYTOMA, UNDETERMINED
Parent(s)
Astrocytic Tumor
Children
Brain Astrocytoma, Pilocytic Astrocytoma, Childhood Astrocytic Tumor, Diffuse Astrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, Pilomyxoid Astrocytoma, Subependymal Giant Cell Astrocytoma, Pleomorphic Xanthoastrocytoma, Adult Astrocytic Tumor, and Anaplastic Astrocytoma
OncoTree Name
Astrocytoma
OncoTree Code
ASTR

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.