Overview

NCI Definition: A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis. [1]

Atypical meningiomas most frequently harbor alterations in NF2, CDKN2A, SMO, ROS1, and PTEN [2].

Most Commonly Altered Genes in Atypical Meningioma

NF2fs, NF2 Mutation, NF2 Nonsense, CDKN2A Loss, and SMO Mutation are the most common alterations in atypical meningioma [2].

Top Alterations in Atypical Meningioma

Significant Genes in Atypical Meningioma

H3F3A +

Disease Details

Synonyms
Atypical meningioma WHO grade II, WHO grade II atypical meningioma
Parent(s)
Grade II Meningioma
OncoTree Name
Atypical Meningioma
OncoTree Code
ATM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.