NCI Definition: A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis. [1]

Atypical meningiomas most frequently harbor alterations in NF2, CDKN2A, SMO, ROS1, and PTEN [2].

Most Commonly Altered Genes in Atypical Meningioma

NF2fs, NF2 Mutation, NF2 Nonsense, CDKN2A Loss, and SMO Mutation are the most common alterations in atypical meningioma [2].

Top Alterations in Atypical Meningioma

Significant Genes in Atypical Meningioma

H3F3A +

Disease Details

Atypical meningioma WHO grade II, WHO grade II atypical meningioma
Grade II Meningioma
OncoTree Name
Atypical Meningioma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.