NCI Definition: A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001) [1]

B-cell lymphoblastic leukemia/lymphomas most frequently harbor alterations in NRAS, KRAS, CDKN2A, TP53, and CDKN2B [2].

Most Commonly Altered Genes in B-Cell Lymphoblastic Leukemia/Lymphoma

NRAS Mutation, KRAS Mutation, NRAS Exon 2 Mutation, NRAS Exon 2 Missense, and KRAS Exon 2 Mutation are the most common alterations in B-cell lymphoblastic leukemia/lymphoma [2].

Top Alterations in B-Cell Lymphoblastic Leukemia/Lymphoma

Significant Genes in B-Cell Lymphoblastic Leukemia/Lymphoma

ABL1 +

ABL2 +





FLT3 +

IL7R +

JAK1 +

JAK2 +

JAK3 +


SH2B3 +

Disease Details

PEDIATRIC B-lymphoblastic leukemia-lymphoma (B-ALL), Precursor B-Lymphoblastic Lymphoma/Leukemia, B Lymphoblastic Leukemia/Lymphoma, Precursor B Lymphoblastic Leukemia/Lymphoma, B-lymphoblastic leukemia-lymphoma (B-ALL)
Precursor Lymphoid Neoplasm
B-Cell Acute Lymphoblastic Leukemia, B-Cell Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified, B-Cell Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities, and B-Cell Lymphoblastic Lymphoma
OncoTree Name
B-Lymphoblastic Leukemia/Lymphoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.