Overview

NCI Definition: A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001) [1]

B-cell lymphoblastic leukemia/lymphomas most frequently harbor alterations in TP53, KRAS, CDKN2A, NRAS, and CREBBP [2].

Most Commonly Altered Genes in B-Cell Lymphoblastic Leukemia/Lymphoma

TP53 Mutation, KRAS Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and NRAS Mutation are the most common alterations in B-cell lymphoblastic leukemia/lymphoma [2].

Top Alterations in B-Cell Lymphoblastic Leukemia/Lymphoma

Disease Details

Synonyms
PEDIATRIC B-lymphoblastic leukemia-lymphoma (B-ALL), Precursor B Lymphoblastic Leukemia/Lymphoma, B Lymphoblastic Leukemia/Lymphoma, B-lymphoblastic leukemia-lymphoma (B-ALL), Precursor B-Lymphoblastic Lymphoma/Leukemia
Parent(s)
Precursor Lymphoid Neoplasm
Children
B-Cell Lymphoblastic Lymphoma, B-Cell Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities, B-Cell Acute Lymphoblastic Leukemia, and B-Cell Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
OncoTree Name
B-Lymphoblastic Leukemia/Lymphoma
OncoTree Code
BLL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.