B-cell neoplasms most frequently harbor alterations in KMT2D, TP53, CREBBP, BCL2, and TNFRSF14 [2].

Most Commonly Altered Genes in B-Cell Neoplasm

CREBBP Mutation, TP53 Mutation, KMT2D Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in B-cell neoplasm [2].

Top Alterations in B-Cell Neoplasm

Disease Details

B-Cell Lymphocytic Neoplasm
Lymphocytic Neoplasm
Mature B-Cell Neoplasm and B-Cell Lymphoblastic Leukemia/Lymphoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.