Overview

NCI Definition: The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas. [1]

Biomarker-Directed Therapies

Significant Genes in Basal Cell Carcinoma

POLE +

PTCH1 +

Disease Details

Synonyms
Skin Basal Cell Carcinoma, BCC, Basal Cell Epithelioma, Invasive Carcinoma c/w Basal Cell Carcinoma, Basal Cell Carcinoma of Skin, Carcinoma c/w Basal Cell Carcinoma, Basal Cell Carcinoma of the Skin, Basal Cell Skin Carcinoma, Basal Cell Cancer
Parent(s)
Keratinocyte Carcinoma
Children
Skin Sarcomatoid Basal Cell Carcinoma, Skin Basosquamous Cell Carcinoma, External Ear Basal Cell Carcinoma, Skin Signet Ring Cell Basal Cell Carcinoma, Vulvar Basal Cell Carcinoma, Skin Morphea-Type (Sclerosing) Basal Cell Carcinoma, Penile Basal Cell Carcinoma, Skin Clear Cell Basal Cell Carcinoma, Superficial Multifocal Basal Cell Carcinoma, Salivary Gland Basal Cell Adenocarcinoma, Scrotal Basal Cell Carcinoma, Prostate Basal Cell Carcinoma, Anal Margin Basal Cell Carcinoma, Skin Adamantinoid Basal Cell Carcinoma, Superficial Basal Cell Carcinoma, Skin Fibroepithelial Basal Cell Carcinoma, and Skin Nodular Basal Cell Carcinoma
OncoTree Name
Basal Cell Carcinoma
OncoTree Code
BCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.