Overview

NCI Definition: An adenocarcinoma that arises from the intrahepatic bile ducts, the hepatic ducts, or the extrahepatic bile ducts. Adenocarcinomas that arise from the intrahepatic bile ducts or the hepatic ducts are called cholangiocarcinomas. [1]

Bile duct adenocarcinomas most frequently harbor alterations in TP53, KRAS, IDH1, ARID1A, and CDKN2A [2].

Most Commonly Altered Genes in Bile Duct Adenocarcinoma

TP53 Mutation, KRAS Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KRAS Exon 2 Mutation are the most common alterations in bile duct adenocarcinoma [2].

Top Alterations in Bile Duct Adenocarcinoma

Significant Genes in Bile Duct Adenocarcinoma

ATM +

ATR +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

MCPH1 +

MRE11A +

NBN +

PALB2 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

Disease Details

Parent(s)
Bile Duct Carcinoma
Children
Cholangiocarcinoma and Bile Duct Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.