Overview

NCI Definition: A benign or malignant neoplasm that affects the intrahepatic or extrahepatic bile ducts. Representative examples of benign neoplasms include bile duct adenoma and extrahepatic bile duct lipoma. Representative examples of malignant neoplasms include intrahepatic and extrahepatic cholangiocarcinoma. [1]

Bile duct neoplasms most frequently harbor alterations in TP53, KRAS, IDH1, ARID1A, and CDKN2A [2].

Most Commonly Altered Genes in Bile Duct Neoplasm

TP53 Mutation, KRAS Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KRAS Exon 2 Mutation are the most common alterations in bile duct neoplasm [2].

Top Alterations in Bile Duct Neoplasm

Disease Details

Synonyms
Bile Duct Tumor, Intrahepatic and Extrahepatic Bile Duct Tumor, Intrahepatic and Extrahepatic Bile Duct Neoplasm
Parent(s)
Biliary Tract Neoplasm
Children
Extrahepatic Bile Duct Neoplasm, Bile Duct Papillary Neoplasm, Malignant Bile Duct Neoplasm, and Bile Duct Adenoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.