NCI Definition: A rare adenocarcinoma arising from metaplastic bladder epithelium. It is frequently associated with long-standing local irritation. The majority of cases originate from the trigone and the posterior wall of the bladder. [1]

Bladder adenocarcinomas most frequently harbor alterations in TP53, PIK3CA, SMAD4, RB1, and KRAS [2].

Most Commonly Altered Genes in Bladder Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and SMAD4 Mutation are the most common alterations in bladder adenocarcinoma [2].

Top Alterations in Bladder Adenocarcinoma

Disease Details

Adenocarcinoma of Urinary Bladder, Adenocarcinoma of the Bladder, Adenocarcinoma of the Urinary Bladder, Urinary Bladder Adenocarcinoma, Adenocarcinoma of Bladder
Bladder Adenocarcinoma, Not Otherwise Specified, Bladder Signet Ring Cell Adenocarcinoma, Bladder Clear Cell Adenocarcinoma, Bladder Enteric Type Adenocarcinoma, Bladder Hepatoid Adenocarcinoma, Bladder Mixed Adenocarcinoma, and Bladder Mucinous Adenocarcinoma
OncoTree Name
Bladder Adenocarcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.