Tuberous sclerosis 1 (TSC1) encodes for a protein, hamartin, that interacts with a protein encoded by the TSC2 gene, tuberin (Genetics Home Reference 2013). TSC1 acts as a tumor suppressor, through regulation of the mTOR pathway, which is involved in cell proliferation (Genetics Home Reference 2013; Sjodahl et al. 2011).
Suggested Citation: Solit, D. 2015. TSC1. My Cancer Genome https://www.mycancergenome.org/content/disease/bladder-cancer/tsc1/?tab=0 (Updated December 7).
Last Updated: December 7, 2015