NCI Definition: A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells distributed in a tubulo-cystic, papillary, or diffuse pattern. There is a female predilection. Clinical presentation includes hematuria and dysuria. [1]

Significant Genes in Bladder Clear Cell Adenocarcinoma

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Clear Cell Adenocarcinoma of the Bladder, Clear Cell Adenocarcinoma of the Urinary Bladder, Clear Cell Adenocarcinoma of Urinary Bladder, Bladder Mesonephric Adenocarcinoma, Urinary Bladder Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma of Bladder
Clear Cell Adenocarcinoma
Bladder Diffuse Clear Cell Adenocarcinoma, Bladder Papillary Clear Cell Adenocarcinoma, and Bladder Tubulo-Cystic Clear Cell Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.