NCI Definition: A highly aggressive carcinoma, histologically resembling small cell lung carcinoma. In most cases it is associated with carcinoma in situ. [1]

Bladder small cell neuroendocrine carcinomas most frequently harbor alterations in TP53, RB1, CREBBP, KMT2D, and FGFR1 [2].

Most Commonly Altered Genes in Bladder Small Cell Neuroendocrine Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 5 Mutation, and TP53 Exon 7 Mutation are the most common alterations in bladder small cell neuroendocrine carcinoma [2].

Top Alterations in Bladder Small Cell Neuroendocrine Carcinoma

Disease Details

Small Cell Neuroendocrine Carcinoma of Urinary Bladder, Small Cell Neuroendocrine Carcinoma of the Urinary Bladder, Bladder Small Cell Carcinoma
Small Cell Carcinoma
OncoTree Name
Small Cell Bladder Cancer
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.