Diseases /
Bladder Small Cell Neuroendocrine Carcinoma
Overview
NCI Definition: A highly aggressive carcinoma, histologically resembling small cell lung carcinoma. In most cases it is associated with carcinoma in situ. [1]
Bladder small cell neuroendocrine carcinomas most frequently harbor alterations in TP53, RB1, CREBBP, KMT2D, and FGFR1 [2].
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 5 Mutation, and TP53 Exon 7 Mutation are the most common alterations in bladder small cell neuroendocrine carcinoma [2].
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.