Overview

NCI Definition: A squamous cell carcinoma of the bladder arising from metaplastic epithelium. It represents less than 10% of bladder carcinomas. The exception is the Middle East along the Nile Valley, where it represents the most common form of carcinoma because of the endemic nature of schistosomiasis. Bladder squamous cell carcinoma is often associated with long-standing chronic inflammation of the bladder and usually has a poor prognosis. The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming. [1]

Bladder squamous cell carcinomas most frequently harbor alterations in TP53, KMT2D, PIK3CA, and CDKN2A [2].

Most Commonly Altered Genes in Bladder Squamous Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and PIK3CA Mutation are the most common alterations in bladder squamous cell carcinoma [2].

Top Alterations in Bladder Squamous Cell Carcinoma

Disease Details

Synonyms
Epidermoid Carcinoma of the Bladder, Epidermoid Carcinoma of the Urinary Bladder, Urinary Bladder Epidermoid Carcinoma, Epidermoid Carcinoma of Bladder, Squamous Cell Carcinoma of the Bladder, Urinary Bladder Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Urinary Bladder, Bladder squamous cell carcinoma (SCC), Bladder Epidermoid Carcinoma, Squamous Cell Carcinoma of Urinary Bladder, Squamous Cell Carcinoma of Bladder, Epidermoid Carcinoma of Urinary Bladder
Parent(s)
Squamous Cell Carcinoma
Children
Bladder Urachal Squamous Cell Carcinoma and Bladder Verrucous Carcinoma
OncoTree Name
Bladder Squamous Cell Carcinoma
OncoTree Code
BLSC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.