NCI Definition: A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage. [1]

Bone neoplasms most frequently harbor alterations in TP53, CDKN2A, CDKN2B, IDH1, and RB1 [2].

Most Commonly Altered Genes in Bone Neoplasm

TP53 Mutation, CDKN2A Loss, CDKN2B Loss, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in bone neoplasm [2].

Top Alterations in Bone Neoplasm

Disease Details

Bone Tumors, Osseous Tumor, Neoplasm of the Bone, Osseous Neoplasm, Bone Tumor, Bone Neoplasms, Neoplasm of Bone, Tumor of the Bone, Tumor of Bone
Connective and Soft Tissue Neoplasm
Malignant Bone Neoplasm, Notochordal Tumor, Benign Bone Neoplasm, and Osteoclastic Giant Cell-Rich Tumor of Bone
OncoTree Name
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.