Bone sarcomas most frequently harbor alterations in IDH1, TP53, CDKN2A, IDH2, and CDKN2B [2].

Most Commonly Altered Genes in Bone Sarcoma

IDH1 Mutation, IDH1 Codon 132 Missense, TP53 Mutation, TP53 c.217-c.1178 Missense, and TP53 c.142-c.212 Missense are the most common alterations in bone sarcoma [2].

Top Alterations in Bone Sarcoma

Significant Genes in Bone Sarcoma

MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Bone Angiosarcoma, Malignancy in Giant Cell Tumor of Bone, Chondrosarcoma, Bone Osteosarcoma, Undifferentiated High Grade Pleomorphic Sarcoma of Bone, Ewing Sarcoma of Bone, and Bone Leiomyosarcoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.