Overview

NCI Definition: A benign or malignant neoplasm that arises from or metastasizes to the brain. [1]

Brain neoplasms most frequently harbor alterations in TP53, KMT2D, PIK3CA, H3F3A, and CTNNB1 [2].

Most Commonly Altered Genes in Brain Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KMT2D Mutation, and H3F3A Mutation are the most common alterations in brain neoplasm [2].

Top Alterations in Brain Neoplasm

Disease Details

Synonyms
Brain Neoplasms, Tumor of the Brain, Tumor of Brain, Neoplasm of Brain, Brain Tumor, Neoplasm of the Brain
Parent(s)
Intracranial Neoplasm
Children
Primary Brain Neoplasm, Supratentorial Neoplasm, Intraventricular Brain Neoplasm, Infratentorial Neoplasm, Benign Brain Neoplasm, Brain Neoplasm, NOS, and Malignant Brain Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.