Overview

NCI Definition: A benign or malignant neoplasm that arises from or metastasizes to the brain. [1]

Brain neoplasms most frequently harbor alterations in TP53, KMT2D, PIK3CA, ATM, and ARID1B [2].

Most Commonly Altered Genes in Brain Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and PIK3CA Mutation are the most common alterations in brain neoplasm [2].

Top Alterations in Brain Neoplasm

Disease Details

Synonyms
Neoplasm of Brain, Tumor of Brain, Neoplasm of the Brain, Brain Neoplasms, Tumor of the Brain, Brain Tumor
Parent(s)
Intracranial Neoplasm
Children
Infratentorial Neoplasm, Malignant Brain Neoplasm, Intraventricular Brain Neoplasm, Supratentorial Neoplasm, Primary Brain Neoplasm, and Brain Neoplasm, NOS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.