NCI Definition: A benign or malignant neoplasm that arises from or metastasizes to the brain. 
Brain neoplasms most frequently harbor alterations in TP53, KMT2D, PIK3CA, H3F3A, and CTNNB1 .
TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KMT2D Mutation, and H3F3A Mutation are the most common alterations in brain neoplasm .
There are 4 clinical trials for brain neoplasm, of which 3 are open and 1 is completed or closed. Of the trials that contain brain neoplasm as an inclusion criterion, 2 are phase 1 (1 open) and 2 are no phase specified (2 open).
Tsma-based slp vaccine, bevacizumab, and neoantigen-based glioblastoma vaccine are the most common interventions in brain neoplasm clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.