NCI Definition: A neuroglial tumor that arises from the brain stem. [1]

Brain stem gliomas most frequently harbor alterations in H3F3A [2].

Most Commonly Altered Genes in Brain Stem Glioma

H3F3A K28M are the most common alterations in brain stem glioma [2].

Top Alterations in Brain Stem Glioma

Disease Details

Glioma of Brain Stem, Glioma of Brainstem, Brain Stem Neuroglial Tumor, Glioma of the Brainstem, Glioma of the Brain Stem, Brainstem Neuroglial Neoplasm, Brain Stem Neuroglial Neoplasm, Brainstem Neuroglial Tumor, Diffuse brainstem glioma, Brainstem Glioma
Primary Brain Stem Neoplasm
Childhood Brain Stem Glioma, Adult Brain Stem Glioma, and Brain Stem Ependymoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.