Overview

NCI Definition: A neuroglial tumor that arises from the brain stem. [1]

Brain stem gliomas most frequently harbor alterations in H3F3A, TP53, PIK3CA, HIST1H3B, and PPM1D [2].

Most Commonly Altered Genes in Brain Stem Glioma

H3F3A Mutation, H3F3A K28M, TP53 Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in brain stem glioma [2].

Top Alterations in Brain Stem Glioma

Disease Details

Synonyms
Glioma of Brain Stem, Brainstem Glioma, Brain Stem Neuroglial Tumor, Brainstem Neuroglial Neoplasm, Brainstem Neuroglial Tumor, Glioma of Brainstem, Diffuse brainstem glioma, Brain Stem Neuroglial Neoplasm, Glioma of the Brainstem, Glioma of the Brain Stem
Parent(s)
Primary Brain Stem Neoplasm
Children
Brain Stem Glioblastoma, Brain Stem Ependymoma, Childhood Brain Stem Glioma, and Adult Brain Stem Glioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.