Brain Stem Glioma
NCI Definition: A neuroglial tumor that arises from the brain stem. 
Brain stem gliomas most frequently harbor alterations in H3F3A .
H3F3A K28M are the most common alterations in brain stem glioma .
There are 3 clinical trials for brain stem glioma, of which 3 are open and 0 are completed or closed. Of the trials that contain brain stem glioma as an inclusion criterion, 1 is phase 1 (1 open) and 2 are phase 1/phase 2 (2 open).
Bevacizumab, gdc-0084, and cetuximab are the most common interventions in brain stem glioma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.